NFIC

Across TCGA cell cohorts, NFIC RNA expression is significantly associated with the go_rna of many other GO terms, with 5,129 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NFIC-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Regulation of anaphase-promoting complex-dependent catabolic process, and Positive regulation of establishment of T cell polarity. Each is linked with NFIC in more than 14 cancer types. Because this analysis shows association rather than direction, both NFIC-to-partner and partner-to-NFIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by NFIC-low versus NFIC-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NFIC→partner) and Y-score (partner→NFIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.129	+1.710	.004	.003	3	15
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.144	+0.942	<.001	<.001	2	14
OVARY	Positive regulation of establishment of T cell polarity →	+0.218	+1.667	<.001	<.001	3	13
SOFT_TISSUE	Metaphase/anaphase transition of cell cycle →	+0.145	+1.058	.001	.001	3	12
LIVER	Positive regulation of cellular response to transforming growth factor beta stimulus →	+0.136	+1.508	<.001	.003	3	12
BONE	Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration →	+0.142	+0.979	.004	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,129 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by NFIC expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →