NFIC

Across TCGA cell cohorts, NFIC mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible NFIC-associated genes across cancer lineages are OR8K3, MS4A6E, and GPR101. Each is linked with NFIC in more than 1 cancer types. Because this analysis shows association rather than direction, both NFIC-to-partner and partner-to-NFIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8K3 grouped by NFIC-low versus NFIC-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFIC→partner) and Y-score (partner→NFIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR8K3 →	+0.004	+4.681	<.001	.003	3	2
SKIN	MS4A6E →	+0.054	+4.415	<.001	.007	3	1
OVARY	GPR101 →	+0.019	+3.990	<.001	.003	3	1
OVARY	OR10A4 →	+0.026	+4.095	.002	.003	3	1
OVARY	OR1L6 →	+0.012	+4.222	<.001	.006	3	1
OVARY	OR2H1 →	+0.027	+4.444	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

OR8K3 by NFIC expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →