NFIA

Across TCGA pan-cancer cohorts, NFIA mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NFIA data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NFIA mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NFIA expression acts as an unfavorable survival marker, although some lineages such as PDAC and COAD show a favorable association.

PDAC, COAD, and LUAD are the cancer types where NFIA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.888	0.581	<.001	66	view →
COAD	DFS	Median	IV	1.000	0.605	.043	18	view →
LUAD	DFS	Tertile	II,III,IV	0.674	0.994	.002	11	view →
GBM	OS	Tertile	All	0.674	0.396	.010	7	view →
CCRCC	OS	Tertile	III,IV	0.836	0.560	.036	3	view →
HNSC	OS	Median	III,IV	1.000	0.948	.043	1	view →
LSCC	OS	Median	All	1.000	0.813	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NFIA–PDAC (DFS)

Open the PDAC breakdown →