NFIA

Across TCGA pan-cancer cohorts, NFIA mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of NFIA’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NFIA mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types NFIA is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and PDAC are the cancer types where NFIA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NFIA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	−1.098	<.001	12	view →
COAD	Female	III,IV	−0.627	<.001	11	view →
PDAC	Female	All	−0.951	<.001	9	view →
LUAD	Female	II,III,IV	−0.908	<.001	9	view →
LSCC	Male	III,IV	−0.815	<.001	9	view →
CCRCC	Male	III,IV	+0.277	<.001	6	view →
OV	All	All	−0.682	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

NFIA–HNSC

Open the HNSC breakdown →