NFIA

Across TCGA patient cohorts, NFIA mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFIA-associated genes across cancer lineages are MEK1, eIF4E, and GAPDH. Each is linked with NFIA in more than 2 cancer types. Because this analysis shows association rather than direction, both NFIA-to-partner and partner-to-NFIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by NFIA-low versus NFIA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFIA→partner) and Y-score (partner→NFIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.383	+2.000	.002	.009	3	3
UCEC	eIF4E →	+0.190	+1.662	.010	.011	3	2
UCEC	GAPDH →	+0.421	+2.415	.026	.003	3	2
UCEC	ACC1 →	+0.275	+2.013	.032	.016	3	2
UCEC	INPP4B →	-0.253	-2.584	.027	.010	3	2
UCEC	JNK_pT183_Y185 →	-0.194	-1.986	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

MEK1 by NFIA expression — UCEC

Explore this box plot interactively →