NFIA

Across TCGA cell cohorts, NFIA mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NFIA-associated genes across cancer lineages are SLC2A7, TLE7, and IL17A. Each is linked with NFIA in more than 1 cancer types. Because this analysis shows association rather than direction, both NFIA-to-partner and partner-to-NFIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC2A7 grouped by NFIA-low versus NFIA-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFIA→partner) and Y-score (partner→NFIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC2A7 →	+0.016	+4.906	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.032	+4.969	<.001	.003	3	1
CNS	IL17A →	+0.008	+4.772	<.001	.002	3	1
LARGE_INTESTINE	GPR63 →	+0.884	+3.502	<.001	.001	3	1
LARGE_INTESTINE	CCNC →	+0.543	+3.502	.005	.001	3	1
LARGE_INTESTINE	HOXD9 →	+0.975	+3.502	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

SLC2A7 by NFIA expression — OESOPHAGUS

Explore this box plot interactively →