NFE4

Across TCGA patient cohorts, NFE4 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,311 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible NFE4-associated proteins across cancer lineages are PTX3, MMP9, and NPM1_S125. Each is linked with NFE4 in more than 3 cancer types. Because this analysis shows association rather than direction, both NFE4-to-partner and partner-to-NFE4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NFE4 versus PTX3 in BRCA, with a Pearson correlation of 0.31.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NFE4→partner) and Y-score (partner→NFE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PTX3 →	+0.587	+1.699	.001	.001	3	4
PDAC	MMP9 →	+0.950	+0.486	.002	.001	3	4
HNSC	NPM1_S125 →	-0.723	-0.876	<.001	.001	3	3
HNSC	PHRF1_S991 →	-0.460	-0.573	<.001	.003	3	3
GBM	ANXA1 →	+0.595	+0.407	.004	.008	3	3
HNSC	MAP1B_S1438 →	-0.599	-0.578	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,311 associations by consensus.

NFE4 vs PTX3 — BRCA

Explore this scatter interactively →