NFE4

Across TCGA cell cohorts, NFE4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,910 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NFE4-associated GO terms across cancer lineages are Regulation of coagulation, Positive regulation of hemostasis, and Positive regulation of blood coagulation. Each is linked with NFE4 in more than 6 cancer types. Because this analysis shows association rather than direction, both NFE4-to-partner and partner-to-NFE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of coagulation grouped by NFE4-low versus NFE4-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NFE4→partner) and Y-score (partner→NFE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of coagulation →	+0.148	+0.568	<.001	.005	3	7
PANCREAS	Positive regulation of hemostasis →	+0.176	+0.924	.002	.002	3	6
PANCREAS	Positive regulation of blood coagulation →	+0.176	+0.924	.002	.002	3	6
PANCREAS	Regulation of hemostasis →	+0.156	+0.599	<.001	.003	3	6
PANCREAS	Regulation of blood coagulation →	+0.156	+0.599	<.001	.003	3	6
SOFT_TISSUE	Skeletal muscle fiber development →	+0.164	+0.547	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,910 associations by consensus.

Regulation of coagulation by NFE4 expression — PANCREAS

Explore this box plot interactively →