NFE2L3

Across TCGA patient cohorts, NFE2L3 mutation is significantly associated with the RNA expression of many other genes, with 830 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFE2L3-associated genes across cancer lineages are SNORD115-41, RNU6-796P, and RNU7-67P. Each is linked with NFE2L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFE2L3-to-partner and partner-to-NFE2L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD115-41 grouped by NFE2L3-low versus NFE2L3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFE2L3→partner) and Y-score (partner→NFE2L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SNORD115-41 →	+0.395	+7.586	<.001	<.001	3	2
LUSC	RNU6-796P →	+0.271	+4.548	.002	.009	3	2
LUSC	RNU7-67P →	+0.519	+5.578	<.001	.002	3	2
CESC	MIR4510 →	+0.196	+4.342	<.001	.007	3	2
HNSC	SDR42E1P4 →	+0.038	+4.441	<.001	.005	3	2
UCEC	TRAJ5 →	+0.490	+1.970	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 830 associations by consensus.

SNORD115-41 by NFE2L3 expression — BRCA

Explore this box plot interactively →