NFE2L2

Across TCGA patient cohorts, NFE2L2 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible NFE2L2-associated genes across cancer lineages are PRDX1, G6PD, and p62 Lck ligand. Each is linked with NFE2L2 in more than 4 cancer types. Because this analysis shows association rather than direction, both NFE2L2-to-partner and partner-to-NFE2L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by NFE2L2-low versus NFE2L2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFE2L2→partner) and Y-score (partner→NFE2L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PRDX1 →	+0.444	+3.459	<.001	.004	3	5
BLCA	G6PD →	+1.604	+3.906	<.001	<.001	3	4
LUSC	p62 Lck ligand →	+0.471	+1.839	.001	<.001	3	3
LUSC	SETD2 →	+0.381	+4.392	<.001	<.001	3	2
BLCA	XRCC1 →	-0.168	-2.115	.019	.018	3	2
LUSC	HER3 →	-0.181	-1.097	.013	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

PRDX1 by NFE2L2 expression — BLCA

Explore this box plot interactively →