NFE2L2

Across TCGA cell cohorts, NFE2L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,129 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NFE2L2-associated GO terms across cancer lineages are Negative regulation of hematopoietic stem cell differentiation, Proteasomal ubiquitin-independent protein catabolic process, and Response to methionine. Each is linked with NFE2L2 in more than 16 cancer types. Because this analysis shows association rather than direction, both NFE2L2-to-partner and partner-to-NFE2L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of hematopoietic stem cell differentiation grouped by NFE2L2-low versus NFE2L2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NFE2L2→partner) and Y-score (partner→NFE2L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of hematopoietic stem cell differentiation →	+0.165	+1.109	<.001	<.001	3	17
LUNG_SCLC	Proteasomal ubiquitin-independent protein catabolic process →	+0.096	+0.736	<.001	.003	3	14
LUNG_SCLC	Response to methionine →	+0.153	+1.094	<.001	<.001	3	11
LUNG_SCLC	Cellular response to methionine →	+0.153	+1.094	<.001	<.001	3	11
LARGE_INTESTINE	Vesicle budding from membrane →	+0.067	+0.802	<.001	<.001	3	11
BONE	Regulation of steroid biosynthetic process →	+0.157	+0.912	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,129 associations by consensus.

Negative regulation of hematopoietic stem cell differentiation by NFE2L2 expression — LUNG_SCLC

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