NFE2L2

Across TCGA cell cohorts, NFE2L2 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NFE2L2-associated genes across cancer lineages are TREML4, PRM2, and POU3F1. Each is linked with NFE2L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFE2L2-to-partner and partner-to-NFE2L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TREML4 grouped by NFE2L2-low versus NFE2L2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFE2L2→partner) and Y-score (partner→NFE2L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TREML4 →	+0.272	+4.044	<.001	<.001	3	2
URINARY_TRACT	PRM2 →	+0.096	+5.087	<.001	.004	3	2
LUNG_NSCLC_LUSC	POU3F1 →	+0.088	+3.222	.005	.004	3	1
OESOPHAGUS	BPIFB4 →	+0.068	+3.137	.001	.003	3	1
OESOPHAGUS	TUBA3C →	+0.026	+3.569	.005	.003	3	1
UPPER_AERODIGESTIVE_TRACT	MMD2 →	+0.036	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

TREML4 by NFE2L2 expression — OESOPHAGUS

Explore this box plot interactively →