NFE2L1

Across TCGA patient cohorts, NFE2L1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFE2L1-associated genes across cancer lineages are 4E-BP1_pT37_T46, mTOR_pS2448, and Rad50. Each is linked with NFE2L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NFE2L1-to-partner and partner-to-NFE2L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT37_T46 grouped by NFE2L1-low versus NFE2L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFE2L1→partner) and Y-score (partner→NFE2L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1_pT37_T46 →	-0.424	-2.321	.006	.006	3	3
UCEC	mTOR_pS2448 →	-0.144	-1.861	.019	.049	3	2
UCEC	Rad50 →	-0.268	-3.000	.007	.001	3	2
UCEC	STAT3_pY705 →	-0.403	-2.459	<.001	.018	3	2
UCEC	ATM →	-0.720	-1.807	<.001	.027	3	2
UCEC	HER3_pY1289 →	+0.070	+2.189	.047	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

4E-BP1_pT37_T46 by NFE2L1 expression — UCEC

Explore this box plot interactively →