NFE2L1

Across TCGA cell cohorts, NFE2L1 mutation is significantly associated with the RNA expression of many other genes, with 185 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NFE2L1-associated genes across cancer lineages are MRAP, CYFIP2, and HTR1A. Each is linked with NFE2L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFE2L1-to-partner and partner-to-NFE2L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRAP grouped by NFE2L1-low versus NFE2L1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFE2L1→partner) and Y-score (partner→NFE2L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MRAP →	+0.028	+4.736	<.001	.009	3	2
LARGE_INTESTINE	CYFIP2 →	+1.293	+3.212	.005	.006	3	2
URINARY_TRACT	HTR1A →	+0.030	+5.087	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	C1orf146 →	+0.028	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	PRR23C →	+0.006	+4.736	<.001	.009	3	1
CNS	PRAMEF15 →	+0.352	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 185 associations by consensus.

MRAP by NFE2L1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →