NFE2L1-DT

Across TCGA pan-cancer cohorts, NFE2L1-DT RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NFE2L1-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NFE2L1-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NFE2L1-DT expression acts as an unfavorable survival marker, although some lineages such as UCS and BLCA show a favorable association.

KIRC, UCS, and LIHC are the cancer types where NFE2L1-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.523	0.717	<.001	141	view →
UCS	OS	Quartile	II,III,IV	0.878	0.115	<.001	96	view →
LIHC	DFS	Median	All	0.465	0.616	<.001	72	view →
ACC	OS	Median	All	0.411	0.812	<.001	65	view →
BLCA	OS	Median	All	0.539	0.337	.001	36	view →
MESO	DFS	Median	II,III,IV	0.262	0.638	.003	30	view →
PRAD	DFS	Tertile	All	0.833	0.959	<.001	20	view →
HNSC	DFS	Tertile	IV	0.713	0.528	.004	19	view →
COAD	OS	Median	All	0.820	0.913	.010	18	view →
STAD	OS	Median	IV	0.642	0.203	.006	15	view →
READ	DFS	Quartile	All	0.871	0.409	.007	15	view →
ESCA	OS	Tertile	IV	0.916	0.219	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NFE2L1-DT–KIRC (OS)

Open the KIRC breakdown →