NFE2

Across TCGA patient cohorts, NFE2 protein abundance is significantly associated with the RNA expression of many other genes, with 7,084 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NFE2-associated genes across cancer lineages are GPR31, ADGRB2, and IPO8. Each is linked with NFE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFE2-to-partner and partner-to-NFE2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NFE2 versus GPR31 in LUAD, with a Pearson correlation of -0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFE2→partner) and Y-score (partner→NFE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GPR31 →	-0.308	-0.639	.002	.006	3	1
LUAD	ADGRB2 →	+0.563	+0.630	.006	.005	3	1
LUAD	IPO8 →	+0.585	+0.753	.005	.003	3	1
LUAD	ARMC5 →	+0.566	+0.693	.005	.009	3	1
LUAD	GALNS →	+0.480	+0.685	<.001	.002	3	1
LUAD	GALNT2 →	+0.521	+0.439	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,084 associations by consensus.

NFE2 vs GPR31 — LUAD

Explore this scatter interactively →