NFE2

Across TCGA patient cohorts, NFE2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFE2-associated genes across cancer lineages are 14-3-3_beta, MEK1, and ATM. Each is linked with NFE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFE2-to-partner and partner-to-NFE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by NFE2-low versus NFE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFE2→partner) and Y-score (partner→NFE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.091	-2.973	.038	.035	3	2
UCEC	MEK1 →	+0.359	+2.115	.024	.019	3	2
UCEC	ATM →	-0.489	-3.308	.013	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.823	+1.894	.001	.030	3	2
UCEC	cIAP →	+0.138	+3.179	.021	.010	3	2
UCEC	4E-BP1 →	+0.293	+3.029	.013	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

14-3-3_beta by NFE2 expression — UCEC

Explore this box plot interactively →