NFE2

Across TCGA cell cohorts, NFE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,407 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NFE2-associated GO terms across cancer lineages are Regulation of intracellular transport, Regeneration, and Protein folding. Each is linked with NFE2 in more than 9 cancer types. Because this analysis shows association rather than direction, both NFE2-to-partner and partner-to-NFE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of intracellular transport grouped by NFE2-low versus NFE2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NFE2→partner) and Y-score (partner→NFE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of intracellular transport →	+0.076	+0.687	<.001	.001	3	10
BREAST	Regeneration →	+0.090	+0.621	<.001	<.001	3	9
BONE	Protein folding →	+0.085	+0.700	<.001	.001	3	9
BONE	Negative regulation of cell migration →	+0.043	+0.438	<.001	<.001	3	8
BONE	Regulation of intracellular protein transport →	+0.076	+0.590	<.001	.007	3	8
BONE	Peptidyl-lysine oxidation →	+1.737	+0.645	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,407 associations by consensus.

Regulation of intracellular transport by NFE2 expression — BONE

Explore this box plot interactively →