NFE2

Across TCGA cell cohorts, NFE2 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NFE2-associated genes across cancer lineages are PHOX2B, PTPN5, and NGF. Each is linked with NFE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFE2-to-partner and partner-to-NFE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHOX2B grouped by NFE2-low versus NFE2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFE2→partner) and Y-score (partner→NFE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PHOX2B →	+0.016	+3.744	<.001	.003	3	2
BLOOD_Leukemia	PTPN5 →	+0.324	+3.934	.007	.002	3	1
BLOOD_Leukemia	NGF →	+0.280	+3.594	<.001	.007	3	1
BLOOD_Leukemia	IL3 →	+0.041	+3.786	<.001	.002	3	1
BLOOD_Leukemia	APOBEC4 →	+0.084	+3.643	<.001	.006	3	1
BLOOD_Leukemia	OR4F17 →	+0.135	+3.479	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PHOX2B by NFE2 expression — BLOOD_Leukemia

Explore this box plot interactively →