NFATC3

Across TCGA patient cohorts, NFATC3 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFATC3-associated genes across cancer lineages are Smac, Caspase-7-cleavedD198, and G6PD. Each is linked with NFATC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFATC3-to-partner and partner-to-NFATC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smac grouped by NFATC3-low versus NFATC3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFATC3→partner) and Y-score (partner→NFATC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Smac →	+0.318	+2.339	.018	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.484	+1.827	.023	.015	3	2
SKCM	G6PD →	-0.217	-2.321	.037	.035	3	1
SKCM	Src_pY527 →	+0.423	+2.321	.047	.035	3	1
UCEC	EGFR_pY1068 →	-0.244	-2.321	.006	.001	3	1
UCEC	A-Raf_pS299 →	-0.098	-2.115	.022	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Smac by NFATC3 expression — SKCM

Explore this box plot interactively →