NFATC3

Across TCGA cell cohorts, NFATC3 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible NFATC3-associated genes across cancer lineages are SERPINA12, TGIF2LY, and SERPINA11. Each is linked with NFATC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFATC3-to-partner and partner-to-NFATC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINA12 grouped by NFATC3-low versus NFATC3-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFATC3→partner) and Y-score (partner→NFATC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SERPINA12 →	+0.102	+4.432	<.001	.003	3	1
STOMACH	TGIF2LY →	+0.133	+4.432	<.001	.003	3	1
STOMACH	SERPINA11 →	+0.970	+4.129	<.001	.007	3	1
LUNG_NSCLC_LUAD	MRGPRX4 →	+0.012	+3.604	<.001	.004	3	1
LUNG_NSCLC_LUAD	WFDC11 →	+0.044	+3.481	.006	.004	3	1
LUNG_NSCLC_LUAD	MAGEB5 →	+0.024	+4.266	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SERPINA12 by NFATC3 expression — STOMACH

Explore this box plot interactively →