NFATC1

Across TCGA cell cohorts, NFATC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,449 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NFATC1-associated GO terms across cancer lineages are Negative regulation of vascular associated smooth muscle cell differentiation, Blood coagulation, intrinsic pathway, and Cell fate commitment. Each is linked with NFATC1 in more than 8 cancer types. Because this analysis shows association rather than direction, both NFATC1-to-partner and partner-to-NFATC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of vascular associated smooth muscle cell differentiation grouped by NFATC1-low versus NFATC1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NFATC1→partner) and Y-score (partner→NFATC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of vascular associated smooth muscle cell differentiation →	-0.189	-0.900	.001	.003	3	9
BREAST	Blood coagulation, intrinsic pathway →	-0.246	-0.961	<.001	.006	3	8
BLOOD_Lymphoma	Cell fate commitment →	-0.062	-2.398	<.001	<.001	3	8
BLOOD_Lymphoma	Regulation of vesicle fusion →	-0.059	-1.824	.001	.002	3	7
CNS	DTMP biosynthetic process →	+0.101	+1.027	.008	<.001	3	6
CNS	Pyrimidine deoxyribonucleoside monophosphate biosynthetic process →	+0.101	+1.027	.008	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,449 associations by consensus.

Negative regulation of vascular associated smooth muscle cell differentiation by NFATC1 expression — LARGE_INTESTINE

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