NFATC1

Across TCGA cell cohorts, NFATC1 mutation is significantly associated with the RNA expression of many other genes, with 1,159 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NFATC1-associated genes across cancer lineages are EAF1, SIKE1, and AVP. Each is linked with NFATC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NFATC1-to-partner and partner-to-NFATC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EAF1 grouped by NFATC1-low versus NFATC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFATC1→partner) and Y-score (partner→NFATC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EAF1 →	+0.587	+3.169	<.001	.009	3	3
LARGE_INTESTINE	SIKE1 →	+0.627	+3.523	.001	<.001	3	3
BLOOD_Lymphoma	AVP →	+0.022	+3.794	<.001	.001	3	2
LUNG_SCLC	IQCF1 →	+0.100	+2.635	<.001	.007	3	2
LUNG_SCLC	FAM187B →	+0.021	+3.232	<.001	.001	3	2
LARGE_INTESTINE	CBY1 →	+0.559	+3.588	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,159 associations by consensus.

EAF1 by NFATC1 expression — LARGE_INTESTINE

Explore this box plot interactively →