NFAT5

Across TCGA pan-cancer cohorts, NFAT5 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of NFAT5’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where NFAT5 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types NFAT5 is over-expressed in tumor, although a few such as CCRCC and LUAD show the opposite, repressed pattern.

CCRCC, LUAD, and PDAC are the cancer types where NFAT5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NFAT5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	II,III,IV	−0.374	<.001	9	view →
LUAD	Female	All	−0.241	<.001	8	view →
PDAC	Female	II,III,IV	−0.394	<.001	7	view →
LSCC	All	All	−0.191	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

NFAT5–CCRCC

Open the CCRCC breakdown →