NFAT5

Across TCGA patient cohorts, NFAT5 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFAT5-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and eEF2. Each is linked with NFAT5 in more than 2 cancer types. Because this analysis shows association rather than direction, both NFAT5-to-partner and partner-to-NFAT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NFAT5-low versus NFAT5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFAT5→partner) and Y-score (partner→NFAT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.422	-3.156	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.571	+2.019	<.001	<.001	3	3
UCEC	eEF2 →	+0.348	+1.716	<.001	.003	3	2
UCEC	eIF4E →	+0.148	+1.321	.011	.005	3	2
UCEC	GAPDH →	+0.384	+1.765	.010	.011	3	2
UCEC	INPP4B →	-0.227	-2.070	.011	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

ATM by NFAT5 expression — UCEC

Explore this box plot interactively →