NFAT5

Across TCGA cell cohorts, NFAT5 mutation is significantly associated with the RNA expression of many other genes, with 261 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NFAT5-associated genes across cancer lineages are OR10K1, SERPINA7, and C1orf158. Each is linked with NFAT5 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFAT5-to-partner and partner-to-NFAT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10K1 grouped by NFAT5-low versus NFAT5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFAT5→partner) and Y-score (partner→NFAT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR10K1 →	+0.004	+3.362	<.001	.007	3	2
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1
KIDNEY	OR56A4 →	+0.006	+5.000	<.001	.005	3	1
KIDNEY	OR56A3 →	+0.026	+5.000	<.001	.005	3	1
KIDNEY	CD300E →	+0.006	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 261 associations by consensus.

OR10K1 by NFAT5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →