NFASC

Across TCGA pan-cancer cohorts, NFASC mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NFASC data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NFASC mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NFASC expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and GBM are the cancer types where NFASC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	IV	0.781	0.220	.017	6	view →
LUAD	DFS	Tertile	All	1.000	0.493	.015	5	view →
GBM	OS	Quartile	All	0.296	0.681	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NFASC–CCRCC (DFS)

Open the CCRCC breakdown →