NFASC

Across TCGA patient cohorts, NFASC mutation is significantly associated with the RNA expression of many other genes, with 6,574 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFASC-associated genes across cancer lineages are OIP5, LDHA, and RAMP2. Each is linked with NFASC in more than 4 cancer types. Because this analysis shows association rather than direction, both NFASC-to-partner and partner-to-NFASC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OIP5 grouped by NFASC-low versus NFASC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFASC→partner) and Y-score (partner→NFASC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OIP5 →	+0.637	+1.399	<.001	<.001	3	5
UCEC	LDHA →	+0.485	+1.479	<.001	<.001	3	5
STAD	RAMP2 →	-0.728	-2.551	<.001	.001	3	5
STAD	MRPS36 →	+0.328	+2.220	.002	.002	3	5
UCEC	KIF18A →	+0.333	+1.262	.006	.007	3	5
STAD	HPRT1 →	+0.432	+2.733	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,574 associations by consensus.

OIP5 by NFASC expression — UCEC

Explore this box plot interactively →