NFASC

Across TCGA patient cohorts, NFASC mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFASC-associated genes across cancer lineages are 4E-BP1, PDCD4, and TFRC. Each is linked with NFASC in more than 4 cancer types. Because this analysis shows association rather than direction, both NFASC-to-partner and partner-to-NFASC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by NFASC-low versus NFASC-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFASC→partner) and Y-score (partner→NFASC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.252	+2.584	.044	.010	3	5
COAD	PDCD4 →	-0.253	-1.700	.043	.040	3	4
STAD	TFRC →	+0.582	+2.584	.026	.010	3	3
STAD	Cyclin-E2 →	+0.238	+3.480	<.001	.002	3	3
LUAD	4E-BP1_pT70 →	+0.297	+3.000	.001	.035	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.245	-0.834	.026	.031	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

4E-BP1 by NFASC expression — STAD

Explore this box plot interactively →