NFASC

Across TCGA cell cohorts, NFASC mutation is significantly associated with the RNA expression of many other genes, with 1,535 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NFASC-associated genes across cancer lineages are SLC13A1, ODF4, and JOSD1. Each is linked with NFASC in more than 1 cancer types. Because this analysis shows association rather than direction, both NFASC-to-partner and partner-to-NFASC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC13A1 grouped by NFASC-low versus NFASC-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFASC→partner) and Y-score (partner→NFASC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC13A1 →	+0.015	+4.614	<.001	.004	3	2
CNS	ODF4 →	+0.045	+4.584	<.001	.001	3	2
LARGE_INTESTINE	JOSD1 →	+0.641	+2.364	<.001	<.001	3	2
LARGE_INTESTINE	MTMR3 →	+0.660	+2.364	<.001	<.001	3	2
LARGE_INTESTINE	UBE2W →	+0.482	+3.169	.006	.009	3	2
LARGE_INTESTINE	ACBD5 →	+0.723	+1.850	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,535 associations by consensus.

SLC13A1 by NFASC expression — PANCREAS

Explore this box plot interactively →