Across TCGA pan-cancer cohorts, NF1P12 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of NF1P12’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NF1P12 RNA is repressed in tumor relative to normal tissue. In most cancer types NF1P12 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
KIRC are the cancer types where NF1P12 tumor–normal differential expression is most reproducible.