NEXN

Across TCGA patient cohorts, NEXN RNA expression is significantly associated with the protein abundance of many other proteins, with 24,268 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NEXN-associated proteins across cancer lineages are NEXN_S365, FERMT2, and KANK2. Each is linked with NEXN in more than 9 cancer types. Because this analysis shows association rather than direction, both NEXN-to-partner and partner-to-NEXN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NEXN versus NEXN_S365 in OV, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NEXN→partner) and Y-score (partner→NEXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NEXN_S365 →	+1.174	+1.118	<.001	<.001	3	10
BRCA	FERMT2 →	+0.681	+1.244	<.001	<.001	3	10
BRCA	KANK2 →	+0.559	+0.857	<.001	<.001	3	10
UCEC	ZYX →	+0.512	+0.947	<.001	<.001	3	9
UCEC	VCL →	+0.532	+0.729	<.001	<.001	3	9
OV	RARRES2 →	+0.735	+1.128	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 24,268 associations by consensus.

NEXN vs NEXN_S365 — OV

Explore this scatter interactively →