NEXN

Across TCGA patient cohorts, NEXN protein abundance is significantly associated with the RNA expression of many other genes, with 14,061 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NEXN-associated genes across cancer lineages are CCN2, CALD1, and CNN1. Each is linked with NEXN in more than 8 cancer types. Because this analysis shows association rather than direction, both NEXN-to-partner and partner-to-NEXN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NEXN versus CCN2 in BRCA, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEXN→partner) and Y-score (partner→NEXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CCN2 →	+1.373	+0.610	<.001	<.001	3	9
BRCA	CALD1 →	+1.206	+0.873	<.001	<.001	3	9
UCEC	CNN1 →	+2.916	+1.217	<.001	<.001	3	9
UCEC	SCN7A →	+1.291	+1.123	<.001	<.001	3	9
CCRCC	FBLN5 →	+1.511	+0.871	<.001	<.001	3	9
BRCA	TGFB1I1 →	+1.164	+0.711	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,061 associations by consensus.

NEXN vs CCN2 — BRCA

Explore this scatter interactively →