NEXN

Across TCGA patient cohorts, NEXN mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEXN-associated genes across cancer lineages are eIF4E, MIG-6, and mTOR_pS2448. Each is linked with NEXN in more than 1 cancer types. Because this analysis shows association rather than direction, both NEXN-to-partner and partner-to-NEXN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NEXN-low versus NEXN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEXN→partner) and Y-score (partner→NEXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.167	+2.000	.014	<.001	3	2
UCEC	MIG-6 →	+0.102	+2.013	.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.204	-2.000	<.001	<.001	3	2
UCEC	PDCD4 →	-0.636	-2.000	<.001	<.001	3	2
UCEC	TFRC →	+0.405	+1.459	.018	.012	3	2
UCEC	ASNS →	+0.377	+1.847	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

eIF4E by NEXN expression — UCEC

Explore this box plot interactively →