NEUROG2

Across TCGA patient cohorts, NEUROG2 mutation is significantly associated with the RNA expression of many other genes, with 3,026 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEUROG2-associated genes across cancer lineages are RNU6-461P, HMGN1P20, and LINC02287. Each is linked with NEUROG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEUROG2-to-partner and partner-to-NEUROG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-461P grouped by NEUROG2-low versus NEUROG2-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEUROG2→partner) and Y-score (partner→NEUROG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RNU6-461P →	+0.303	+7.977	<.001	.007	3	2
UCEC	HMGN1P20 →	+0.153	+2.373	<.001	.002	3	2
UCEC	LINC02287 →	+0.094	+1.939	.003	.003	3	2
UCEC	ZNF280A →	+1.028	+2.839	<.001	.001	3	2
LGG	RNU6-715P →	+0.313	+7.977	<.001	.007	3	1
LGG	MIR519C →	+0.358	+7.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,026 associations by consensus.

RNU6-461P by NEUROG2 expression — LGG

Explore this box plot interactively →