NEUROG1

Across TCGA patient cohorts, NEUROG1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEUROG1-associated genes across cancer lineages are A-Raf_pS299, FOXO3a_pS318_S321, and JNK_pT183_Y185. Each is linked with NEUROG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEUROG1-to-partner and partner-to-NEUROG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by NEUROG1-low versus NEUROG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEUROG1→partner) and Y-score (partner→NEUROG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.176	-2.999	.002	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.190	-2.449	.001	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.284	-3.321	<.001	.009	3	1
UCEC	JNK2 →	+0.353	+3.196	<.001	.009	3	1
UCEC	MIG-6 →	+0.135	+2.179	.004	.034	3	1
UCEC	mTOR_pS2448 →	-0.227	-3.439	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

A-Raf_pS299 by NEUROG1 expression — UCEC

Explore this box plot interactively →