NEUROD4

Across TCGA pan-cancer cohorts, NEUROD4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NEUROD4 data layer compared with 18 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher NEUROD4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated NEUROD4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

LIHC, SKCM, and ESCA are the cancer types where NEUROD4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.083	0.559	<.001	18	view →
SKCM	OS	Median	II,III,IV	0.901	0.712	.004	14	view →
ESCA	OS	Median	All	0.411	0.704	.001	11	view →
UCEC	DFS	Median	All	0.917	0.623	.027	4	view →
SARC	DFS	Median	All	0.121	0.591	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NEUROD4–LIHC (DFS)

Open the LIHC breakdown →