NEUROD2

Across TCGA patient cohorts, NEUROD2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEUROD2-associated genes across cancer lineages are Rad50, ACC1, and TSC1. Each is linked with NEUROD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEUROD2-to-partner and partner-to-NEUROD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by NEUROD2-low versus NEUROD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEUROD2→partner) and Y-score (partner→NEUROD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.368	-3.000	.008	.037	3	2
UCEC	ACC1 →	+0.467	+3.000	.026	.037	3	1
UCEC	TSC1 →	-0.212	-3.000	.032	.037	2	2
UCEC	ERK2 →	+0.276	+3.000	.013	.037	2	1
UCEC	SCD →	+0.174	+3.013	.006	.019	2	1
UCEC	STAT3_pY705 →	-0.361	-3.000	.017	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Rad50 by NEUROD2 expression — UCEC

Explore this box plot interactively →