NEUROD2

Across TCGA cell cohorts, NEUROD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,119 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible NEUROD2-associated GO terms across cancer lineages are Response to mechanical stimulus, Regulation of macroautophagy, and Negative regulation of DNA-templated transcription initiation. Each is linked with NEUROD2 in more than 5 cancer types. Because this analysis shows association rather than direction, both NEUROD2-to-partner and partner-to-NEUROD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to mechanical stimulus grouped by NEUROD2-low versus NEUROD2-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NEUROD2→partner) and Y-score (partner→NEUROD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Response to mechanical stimulus →	-0.034	-0.019	.003	.007	3	6
BLOOD_Lymphoma	Regulation of macroautophagy →	+0.054	+0.060	<.001	.006	3	6
BLOOD_Leukemia	Negative regulation of DNA-templated transcription initiation →	+0.104	+0.045	<.001	.001	3	5
BLOOD_Leukemia	Negative regulation of transcription initiation by RNA polymerase II →	+0.104	+0.045	<.001	.001	3	5
BLOOD_Lymphoma	Positive regulation of proteasomal protein catabolic process →	+0.066	+0.093	<.001	.004	3	5
BLOOD_Leukemia	Positive regulation of calcium ion transport →	-0.057	-0.025	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,119 associations by consensus.

Response to mechanical stimulus by NEUROD2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →