NEUROD2

Across TCGA cell cohorts, NEUROD2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEUROD2-associated genes across cancer lineages are MRGPRG, OR4C12, and CLRN2. Each is linked with NEUROD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEUROD2-to-partner and partner-to-NEUROD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRGPRG grouped by NEUROD2-low versus NEUROD2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEUROD2→partner) and Y-score (partner→NEUROD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MRGPRG →	+0.026	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.017	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	CLRN2 →	+0.065	+5.189	<.001	<.001	3	1
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	C1orf68 →	+0.024	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR4A47 →	+0.022	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MRGPRG by NEUROD2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →