NEURL3

Across TCGA patient cohorts, NEURL3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEURL3-associated genes across cancer lineages are EGFR_pY1173, IGFBP2, and p90 RSK. Each is linked with NEURL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEURL3-to-partner and partner-to-NEURL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by NEURL3-low versus NEURL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEURL3→partner) and Y-score (partner→NEURL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	-0.085	-3.149	.043	.019	3	1
UCEC	IGFBP2 →	-0.693	-3.321	.042	.010	3	1
UCEC	p90 RSK →	+0.202	+3.009	.043	.019	3	1
UCEC	Annexin-1 →	+0.776	+3.189	.004	.010	3	1
UCEC	PI3K-p85 →	+0.289	+2.817	.008	.036	2	1
UCEC	ASNS →	+0.532	+3.000	.004	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

EGFR_pY1173 by NEURL3 expression — UCEC

Explore this box plot interactively →