Across TCGA pan-cancer cohorts, NEU4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of NEU4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NEU4 RNA is repressed in tumor relative to normal tissue. In most cancer types NEU4 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and KIRP are the cancer types where NEU4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NEU4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−2.124	<.001	11	view →
KICH	Male	II,III,IV	−1.613	<.001	10	view →
KIRP	All	III,IV	−1.553	<.001	9	view →
KIRC	Male	All	−0.852	<.001	7	view →
CHOL	Female	All	−4.046	<.001	5	view →
LIHC	Female	All	−1.585	.003	4	view →
HNSC	All	All	−0.467	.009	4	view →
BRCA	Female	All	+0.165	.002	4	view →
THCA	Male	III,IV	−0.404	.014	3	view →
READ	All	All	−1.498	.008	2	view →
UCEC	All	II,III,IV	−0.862	.047	2	view →
STAD	Female	III,IV	+0.469	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

Exploration

Same gene, other analysis: NEU4 RNA expression & survival · all NEU4 data types