NEU3

Across TCGA patient cohorts, NEU3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEU3-associated genes across cancer lineages are STAT3_pY705, VHL, and ATM. Each is linked with NEU3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEU3-to-partner and partner-to-NEU3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by NEU3-low versus NEU3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEU3→partner) and Y-score (partner→NEU3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.521	-2.584	<.001	.011	3	1
UCEC	VHL →	-1.231	-3.321	<.001	.010	3	1
UCEC	ATM →	-0.706	-3.156	<.001	.018	3	1
UCEC	Bak →	+0.274	+3.169	.019	.019	3	1
UCEC	c-Met_pY1235 →	+0.091	+2.331	.008	.019	3	1
UCEC	4E-BP1 →	+0.339	+3.029	.007	.018	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

STAT3_pY705 by NEU3 expression — UCEC

Explore this box plot interactively →