NEU3

Across TCGA cell cohorts, NEU3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEU3-associated genes across cancer lineages are SYCN, ITGAD, and BPIFB6. Each is linked with NEU3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEU3-to-partner and partner-to-NEU3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYCN grouped by NEU3-low versus NEU3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEU3→partner) and Y-score (partner→NEU3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SYCN →	+0.051	+5.539	<.001	.003	3	1
LARGE_INTESTINE	ITGAD →	+0.009	+2.925	.003	.007	3	1
LARGE_INTESTINE	BPIFB6 →	+0.014	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR10W1 →	+0.014	+3.562	<.001	.002	3	1
LARGE_INTESTINE	SAMD7 →	+0.014	+2.878	.002	.009	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.008	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SYCN by NEU3 expression — BLOOD_Leukemia

Explore this box plot interactively →