NEU3

Across TCGA cell cohorts, NEU3 mutation is significantly associated with the mutation status of many other genes, with 4,521 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEU3-associated genes across cancer lineages are EGR1, CLOCK, and TTC16. Each is linked with NEU3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NEU3-to-partner and partner-to-NEU3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGR1 grouped by NEU3-low versus NEU3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEU3→partner) and Y-score (partner→NEU3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EGR1 →	+3.672	+5.083	.001	.001	1	3
BLOOD_Leukemia	CLOCK →	+4.479	+5.635	<.001	<.001	1	3
LARGE_INTESTINE	TTC16 →	+3.263	+4.056	<.001	<.001	1	3
LARGE_INTESTINE	TBX10 →	+3.584	+3.007	.008	.008	1	3
BLOOD_Leukemia	RNF139 →	+4.309	+4.560	.007	.007	1	3
LARGE_INTESTINE	RASGRP1 →	+4.584	+3.350	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,521 associations by consensus.

EGR1 by NEU3 expression — BLOOD_Leukemia

Explore this box plot interactively →