NET1

Across TCGA pan-cancer cohorts, NET1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NET1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where NET1 RNA is repressed in tumor relative to normal tissue. In most cancer types NET1 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, LUAD, and LUSC are the cancer types where NET1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NET1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−3.038	<.001	10	view →
LUAD	Male	II,III,IV	+1.769	<.001	9	view →
LUSC	Male	II,III,IV	+1.936	<.001	8	view →
KIRP	All	III,IV	−0.810	<.001	8	view →
BRCA	All	II,III,IV	+0.469	<.001	6	view →
STAD	Male	All	+0.922	<.001	5	view →
CHOL	All	II,III,IV	+2.095	.009	4	view →
COAD	Female	All	−0.594	.002	4	view →
LIHC	All	All	+0.486	<.001	4	view →
BLCA	Male	IV	+1.964	.016	2	view →
UCEC	All	All	−0.452	.038	2	view →
PRAD	All	All	+0.354	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NET1–KICH

Open the KICH breakdown →