NEPRO

Across TCGA patient cohorts, NEPRO mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEPRO-associated genes across cancer lineages are eEF2, eIF4E, and JNK2. Each is linked with NEPRO in more than 2 cancer types. Because this analysis shows association rather than direction, both NEPRO-to-partner and partner-to-NEPRO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by NEPRO-low versus NEPRO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEPRO→partner) and Y-score (partner→NEPRO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.417	+3.700	<.001	.001	3	2
UCEC	eIF4E →	+0.182	+2.700	.014	.006	2	3
UCEC	JNK2 →	+0.156	+1.662	.026	.011	3	2
UCEC	Shc_pY317 →	-0.108	-1.362	.043	.037	3	2
UCEC	STAT3_pY705 →	-0.288	-1.362	.001	.037	3	2
UCEC	TFRC →	+0.380	+1.362	.043	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eEF2 by NEPRO expression — UCEC

Explore this box plot interactively →