Across TCGA pan-cancer cohorts, NENFP2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of NENFP2’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NENFP2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NENFP2 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
KIRC and BRCA are the cancer types where NENFP2 tumor–normal differential expression is most reproducible.