NEMF

Across TCGA patient cohorts, NEMF mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEMF-associated genes across cancer lineages are Akt, EGFR_pY1068, and mTOR_pS2448. Each is linked with NEMF in more than 1 cancer types. Because this analysis shows association rather than direction, both NEMF-to-partner and partner-to-NEMF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt grouped by NEMF-low versus NEMF-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEMF→partner) and Y-score (partner→NEMF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Akt →	-0.627	-2.991	.008	.036	3	2
UCEC	EGFR_pY1068 →	-0.199	-1.353	.011	.015	3	2
UCEC	mTOR_pS2448 →	-0.123	-1.893	.008	.014	3	2
UCEC	Akt_pT308 →	+0.401	+1.353	.043	.015	3	2
UCEC	PDCD4 →	-0.475	-1.836	.001	.001	3	2
UCEC	ASNS →	+0.364	+1.662	.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Akt by NEMF expression — COAD

Explore this box plot interactively →