Across TCGA pan-cancer cohorts, NELL2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated NELL2 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher NELL2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NELL2 expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

GBM and HNSC are the cancer types where NELL2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.807	0.625	.006	10	view →
HNSC	DFS	Tertile	III,IV	1.000	0.601	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: NELL2 tumor-vs-normal RNA expression · all NELL2 data types